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English: An enzyme binding site that would normally bind substrate can alternatively bind a competitive inhibitor, preventing substrate access. Dihydrofolate reductase is inhibited by methotrexate which prevents binding of its substrate, folic acid. Binding site in blue, inhibitor in green, and substrate in black. (PDB: 4QI9​)
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Xigasho Shaqadayda
Qoraa Thomas Shafee
Other versions For scalar version, see File:DHFR methotrexate inhibitor.png

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